Biopharma Filters

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  • sales@biopharmafilters.com
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TFF (Tangential Flow Filtration) Filters

TFF (Tangential Flow Filtration) Filters

  • Description:Tangential Flow for concentration & diafiltration.
  • Applications: Protein purification, virus clearance, buffer exchange.
  • Formats: Hollow fiber modules, cassettes.
  • Materials:Polysulfone, PVDF, PES.
  • MWCO: 10 kDa – 750 kDa.
  • Compliance: USP, ISO 11137.
  • SOP (Summary):
    1. Flush with NaOH or WFI.
    2. Monitor TMP and crossflow rates.
  • Client Customizations: Gamma-stable configurations.
  • Process Notes: Reusable if cleaned properly.
  • Features:
    1. Ultrafiltration and diafiltration cassettes
    2. Hollow fiber modules (10 kDa to 750 kDa MWCO)

Description:

TFF filters enable high-efficiency ultrafiltration and diafiltration in biopharmaceutical manufacturing. They use membranes in hollow fiber or cassette formats for concentrating, buffer exchanging, and purifying proteins, mAbs, or vaccines. TFF offers higher flux and lower fouling by running parallel to the membrane surface. MWCOs range from 1 kDa to 750 kDa, supporting diverse biomolecule sizes. These filters meet cGMP requirements and are scalable from R&D to commercial manufacturing. Compatible with CIP/SIP and gamma irradiation, TFF systems are critical in downstream processing workflows such as viral clearance and protein refolding.